Mississippi Pot Roast Sandwiches. A great way to use up leftovers or perfect for entertaining.
How to Make Mississippi Pot Roast post is here.
I share how to make in a crockpot, dutch oven or instant pot.
Mississippi Pot Roast Variations
Whether you stick with the OG beef chuck roast or shake things up with unexpected ingredients, these tweaks will keep your friends (and your taste buds) on their toes:
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Smoky Chipotle Twist: Swap half the pepperoncini juice for adobo sauce and add a smoked paprika sprinkle.
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Herb & Garlic Kick: Tuck in fresh garlic cloves and a rosemary sprig under the roast before braising for garden-fresh aroma.
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Creamy Ranch Upgrade: Stir in a few ounces of cream cheese or Greek yogurt at the end for ultra-silky pan sauce.
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Veggie-Packed Version: Layer onion wedges, carrots, and baby potatoes beneath the roast so they soak up every drop of that pepperoncini–butter blend.
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Giardiniera: Substitute Giardiniera for the pepperoncinis.
(see more Mississippi pot roast variations to elevate your dinner game!)

Leftover Mississippi Pot Roast Sandwiches
Ingredients
- Leftover Mississippi Pot Roast
- Crusty hoagie rolls
- Butter
- Mayonaise (optional)
- Provolone cheese
- Pepperoncini peppers, sliced
Instructions
- Slice and toast hoogie rolls
- Butter one side of the the roll. Add mayo if using.
- Top the buttered side with the shredded beef. (the butter helps prevent the roll from getting soggy)
- Add cheese, and place under the broiler until melted. Watch it, it only takes a few seconds. Add sliced Pepperoncini and serve.
Notes:
- If making these for a party, use slider rolls. Preheat oven to 375 degrees. Place entire package of rolls into a 9x13" baking pan and remove the top half of the buns. (The buns should fit perfectly in the pan)
- Slather the shredded Mississippi Roast onto the buns so it is 1" thick. Cover the meat with slices of Provolone Cheese. Add the top of the roll. Cover baking pan in foil. Baking pan may now be placed in the refrigerator until ready to be cooked, or you can proceed with baking
- Bake the covered pan for 10 minutes, then remove the foil and bake for 10 minutes further, or until golden brown.
Other Great Mississippi Pot Roast Leftover Recipes!
Think tacos, grilled cheese, and these recipes below!
Beef & Noodles Recipe
Mississippi Pot Roast Enchiladas
Shepherd's Pie with Leftover Pot Roast

Mississippi Pot Roast Sliders
Equipment
- Sheet Pan
Ingredients
- Leftover Mississippi Pot Roast
- Crusty hoagie rolls
- Butter
- Mayonaise optional
- Provolone cheese
- Pepperoncini peppers sliced
Instructions
- Slice and toast hogie rolls
- Butter one side of the the roll. Add mayo if using.
- Top the buttered side with the shredded beef. (the butter or a layer of cheese helps prevent the roll from getting soggy)
- Add cheese, and place under the broiler until melted. Watch it, it only takes a few seconds. Add sliced Pepperoncini and serve.